Which hawaii island is best on This model has been characterized as a human stress response in females that is secondary to the classic fight-or-flight response. Neuroendocrinal evidence from animal and human research suggests an underlying physiological mechanism mediated by oxytocin and moderated by female sex hormones and opioid peptide mechanisms. tender-mindedness n. a personality trait characterized by intellectualism, idealism, optimism, dogmatism, religiousness, and monism. Compare toughmindedness. -tender-minded adj. tension n. Which hawaii island is best 2016.