Kerman Travel on Infuriated, Manco secretly mobilized his army and prepared stores of weapons. He escaped from Cuzco in April 1536 and assembled his chiefs in a ceremony at which they swore to drive the hated invaders from Peru. In May the 190 Spaniards in Cuzco found themselves surrounded by Indian forces. Manco's rebellion lasted until December.
Four expeditions sent by Pizarro to reinforce his brothers in Cuzco were all wiped out as they marched through mountain defiles.
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Some 500 Spaniards were killed, but the Peruvians failed to liberate their country. Shiploads of Spanish soldiers arrived from Central America, and the siege of Cuzco was broken.
Kerman Travel 2016.